ASSOCIATION OF TNF AND LTA GENES WITH ATHEROSCLEROSIS COMPLICATIONSIN PATIENTS WITH HISTORY OF ACUTE CORONARY SYNDROME
| العنوان: | ASSOCIATION OF TNF AND LTA GENES WITH ATHEROSCLEROSIS COMPLICATIONSIN PATIENTS WITH HISTORY OF ACUTE CORONARY SYNDROME |
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| المؤلفون: | N A Koziolova, Alexey Nikitin, Dzhaiani Na, Evgeniya V. Akatova, K A Blagodatskih, A N Brovkin, E. G. Volkova, O. I. Boyeva, S. V Shlyk, S N Tereschenko, A. S. Galyavich, AA Pushkov, V. O. Konstantinov, Baklanova Tn, E V Horolets, A V Yagoda, Nosikov Vv, Glezer Mg, Evdokimova Ma, D A Zateyshchikov |
| المصدر: | Journal of Clinical Practice. 4:4-11 |
| بيانات النشر: | ECO-Vector LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Acute coronary syndrome, business.industry, medicine.disease, Gastroenterology, Genetic marker, Internal medicine, Genotype, medicine, Disease Exacerbation, In patient, Tumor necrosis factor alpha, Allele, business, Gene |
| الوصف: | The aim of this study was to investigate an association of polymorphic markers G(-308)A of TNF gene and Thr26Asn of LTA gene with the frequency of poor outcomes in patients with the history of acute coronary syndrome.Methods. A total of 1145 patients admitted to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don with ischemic heart disease exacerbation were examined. The maximum follow up time was 3.2 years. The identification of polymorphic marker allele was carried out by hybridization-fluorescent analysis using real-time polymerase chain reaction.Results. In case of Thr26Asn polymorphic marker of LTA gene we have not found any association with the frequency of poor outcomes in patients with the history of acute coronary syndrome. However, in case of G(-308)A polymorphic marker of TNF gene we have found the reliable association. The carriers of GA and AA genotypes has higher frequency of poor outcomes in comparison with the carriers of GG genotypes. The survival time to the endpoint for carriers of the GA and AA genotypes was 43.3 months (95% CI = 40.04 - 46.56) vs. 49.6 months (95% CI = 47.38 - 51.82) for carriers of theGG genotype (χ2 = 15.4; р < 0.001).The results of our study allow to make a conclusion that the G(-308)A polymorphic marker of TNF gene is significantly associated with hereditary predisposition to unfavourable outcome in patients with history of acute coronary syndrome. |
| تدمد: | 2618-8627 2220-3095 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b0457bea4a61ec4a307bdf540174ccd9 https://doi.org/10.17816/clinpract414-11 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b0457bea4a61ec4a307bdf540174ccd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26188627 22203095 |
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