Talimogene laherparepvec pseudolymphomatous reaction mimicking metastatic melanoma
| العنوان: | Talimogene laherparepvec pseudolymphomatous reaction mimicking metastatic melanoma |
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| المؤلفون: | Ania Henning, Doreen M. Agnese, Catherine Chung |
| المصدر: | Journal of Cutaneous Pathology. 48:1423-1426 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | CD20, education.field_of_study, Pathology, medicine.medical_specialty, Histology, biology, business.industry, Melanoma, medicine.medical_treatment, Population, Dermatology, Immunotherapy, medicine.disease, Pathology and Forensic Medicine, Oncolytic virus, biology.protein, medicine, Stage IIIC, Histopathology, Talimogene laherparepvec, education, business |
| الوصف: | Talimogene laherparepvec (TVEC) is a genetically modified herpes simplex virus-1 approved as an intralesional oncolytic immunotherapy for the treatment of advanced melanoma. Cutaneous reactions at the site of injection may mimic recurrent or progressive melanoma; histopathological findings have included chronic granulomatous dermatitis, neutrophilic dermatitis, lymphocytic dermatitis, and pigment incontinence. We report a 39-year-old male with metastatic stage IIIc melanoma treated with TVEC with clinical regression of melanoma lesions that later developed pink nodules at sites of prior injection. Histopathology demonstrated a nodular mononuclear infiltrate that stained strongly and diffusely with CD45 and CD20 with a surrounding rim of CD3-positive T-cells. Immunoglobulin gene rearrangement was negative for a clonal B-cell population. To our knowledge, this is the first report of a pseudolymphomatous reaction mimicking recurrent melanoma after TVEC therapy. |
| تدمد: | 1600-0560 0303-6987 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b1160afd946d3981a98f34123c028c3e https://doi.org/10.1111/cup.14094 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........b1160afd946d3981a98f34123c028c3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000560 03036987 |
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