Retention of configuration at C-3 of (2S,3S)-[4-13C] valine in the biosynthesis of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine, the acyclic precursor of the penicillins
التفاصيل البيبلوغرافية
العنوان:
Retention of configuration at C-3 of (2S,3S)-[4-13C] valine in the biosynthesis of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine, the acyclic precursor of the penicillins
(2S,3S)-[4-13C]Valine has been incorporated into the title compound (1) by a β-lactam negative mutant of Cephalosprium acremonium; isolation [as the corresponding sulphonic acid (1a) and subsequent hydrolysis afforded (2R,3S)-4-13C]valine, showing retention of the chirality at the 3-position.
