SUMMARY Background: Anxiety and depression are common features of coeliac disease. Depression is cause of noncompliance to treatment in chronic illness. Aim: To evaluate the useful of psychological support counselling to improve affective disorders and glutenfree diet adherence in coeliac disease with anxiety and depression. Methods: A total of 66 coeliac disease patients with state anxiety and current depression were enrolled. Patients were randomized in two groups: in group A psychological support was started at the beginning of gluten-free diet, while group B was free of psychological support. Both groups were followed every 2 weeks for 6 months. State and Trait Anxiety Inventory test Y-1 and the modified Zung self-rating depression scale were administered before (T0) and after 6 months of glutenfree diet (T1). Results: At T1 no difference was found between groups in the percentage of state anxiety, while a significant lower percentage of depressed subjects was found in group A with respect to group B (15.1% vs. 78.8%; P ¼ 0.001). In the follow-up period, a significant lower compliance to gluten-free diet was found in group B with respect to group A (39.4% vs. 9.1%; P ¼ 0.02). Conclusions: In coeliac disease patients with affective disorders psychological support seems to be able to reduce depression and to increase gluten-free diet compliance.
