Imaging of post-infarct myocardial inflammation with 68Ga-DOTATATE PET/MRI
| العنوان: | Imaging of post-infarct myocardial inflammation with 68Ga-DOTATATE PET/MRI |
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| المؤلفون: | A Corovic, M Nus, M Peverelli, D Gopalan, P A Calvert, S P Hoole, R Manavaki, T Fryer, L Aloj, M J Graves, M R Dweck, D E Newby, Z Mallat, J H F Rudd, J M Tarkin |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background After myocardial infarction (MI), inflammation and its resolution modulate the extent of myocardial damage. 68Ga-DOTATATE is a PET tracer that binds to somatostatin receptor 2 (SST2), which is up-regulated in pro-inflammatory macrophages [1]. Purpose We investigated 68Ga-DOTATATE PET/MRI for quantifying post-infarct myocardial inflammation. Methods In this prospective observational cohort study, participants with MI underwent 68Ga-DOTATATE PET/MRI at baseline (t0: Results Thirty-two patients (mean age 59 [SD 9] years; 26 [81%] male and 6 [19%] female), comprised of 18 (56%) patients with ST elevation MI and 14 (44%) with non-ST elevation MI, were enrolled. Mean peak troponin was 16,953ng/L (range 408 to >25,000ng/L), and 16 (52%) patients had left ventricular impairment (ejection fraction 68Ga-DOTATATE PET signal co-localised with myocardial LGE and focal oedema (arrows) on T2-weighted MRI (Fig. 1; asterisk: culprit artery) and had excellent ability to discriminate infarct from remote regions (t0: infarct SUV 2.41 vs. remote 1.58, p At 100 (SD 13) days after MI (n=23 patients), residual 68Ga-DOTATATE uptake in the infarct remained higher than remote myocardium (t3M: infarct SUV 1.88 vs. remote 1.27, p Reduction in infarct 68Ga-DOTATATE uptake was consistent with overall decreases in hsCRP (2.16 vs. 8.76 mg/L), hsTnI (19 vs. 1365 ng/L) and NTproBNP (372 vs. 959 pg/mL) at t3M vs. t0 (n=23, all p Conclusions This is the first prospective study of serial 68Ga-DOTATATE PET/MRI in patients after MI. Here we show that 68Ga-DOTATATE tracks resolving myocardial inflammation. Ongoing work as part of this study seeks to confirm the cellular origin of infarct-related 68Ga-DOTATATE PET signal and SST2 expression within inflamed myocardial tissue, and test its longer-term association with ischaemic myocardial remodelling. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Wellcome TrustBritish Heart Foundation |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b332712105e75801857930ea2e42ac5c https://doi.org/10.1093/eurheartj/ehac544.321 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........b332712105e75801857930ea2e42ac5c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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