Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
| العنوان: | Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus |
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| المؤلفون: | David Artis, Cliff Y Yang, Michael C. Abt, Ananda W. Goldrath, E. John Wherry, Jill M. Angelosanto, Travis A. Doering, Joshua M. Diamond, Masaru Kubota, Ronald G. Collman, Taheri Sathaliyawala, Carly G. K. Ziegler, Donna L. Farber, Brian J. Laidlaw, Gregory F. Sonnenberg, Damian Turner, Laurel A. Monticelli, Theresa Alenghat |
| المصدر: | Nature Immunology. 12:1045-1054 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | education.field_of_study, Immunology, Orthomyxoviridae, Innate lymphoid cell, Population, Inflammation, respiratory system, Biology, biology.organism_classification, respiratory tract diseases, body regions, Interleukin 33, Immune system, medicine, Immunology and Allergy, medicine.symptom, skin and connective tissue diseases, Interleukin-7 receptor, education, Tissue homeostasis |
| الوصف: | Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus. |
| تدمد: | 1529-2916 1529-2908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b385a80f9ce795479534ae7b42f35666 https://doi.org/10.1038/ni.2131 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b385a80f9ce795479534ae7b42f35666 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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