Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI
| العنوان: | Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI |
|---|---|
| المؤلفون: | Jean François Payen, Olivier Montigon, Emmanuel Briot, Irène Troprès, Michel Décorps, Cécile Julien-Dolbec |
| المصدر: | NMR in Biomedicine. 13:384-391 |
| بيانات النشر: | Wiley, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, business.industry, Hemodynamics, Blood volume, medicine.disease, Blood pressure, medicine.anatomical_structure, Cerebral blood flow, Hypocapnia, Internal medicine, Anesthesia, medicine, Cardiology, Molecular Medicine, Radiology, Nuclear Medicine and imaging, business, Spectroscopy, Emission computed tomography, circulatory and respiratory physiology, Blood vessel, Intracranial pressure |
| الوصف: | We used steady-state susceptibility contrast MRI to evaluate the regional cerebral blood volume (rCBV) response to hypocapnia in anesthetised rats. The rCBV was determined in the dorsoparietal neocortex, the corpus striatum, the cerebellum, as well as blood volume in extracerebral tissue (group 1). In addition, we used laser-Doppler flow (LDF) measurements in the left dorsoparietal neocortex (group 2), to correlate changes in CBV and in cerebral blood flow. Baseline values, expressed as a percentage of blood volume in each voxel, were higher in the brain regions than in extracerebral tissue. Hypocapnia (PaCO2 ≈ 25 mmHg) resulted in a significant decrease in CBV in the cerebellum (−17 ± 9%), in the corpus striatum (−15 ± 6%) and in the neocortex (−12 ± 7%), compared to the normocapnic CBV values (group 1). These changes were in good agreement with the values obtained using alternative techniques. No significant changes in blood volume were found in extracerebral tissue. The CBV changes were reversed during the recovery period. In the left dorsoparietal neocortex, the reduction in LDF (group 2) induced by hypocapnia (−21 ± 8%) was in accordance with the values predicted by the Poiseuille's law. We conclude that rCBV changes during CO2 manipulation can be accurately measured by susceptibility contrast MRI. Copyright © 2000 John Wiley & Sons, Ltd. Abbreviations used: ANOVA analysis of variancce CBF cerebral blood flow CBV cerebral blood volume CPMG Carr–Purcell–Meiboom–Gill FiO2 fractional inspired oxygen ICP intracranial pressure LDF laser-Doppler flow MABP mean arterial blood pressure MRI magnetic resonance imaging MTT mean transit time PaCO2 arterial partial pressure of carbon dioxide PaO2 arterial partial pressure of oxygen PET positron emission tomography rCBV regional cerebral blood volume SPECT single-photon emission computed tomography |
| تدمد: | 1099-1492 0952-3480 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b3a77cd516a392f52b7e6a7e00015c70 https://doi.org/10.1002/1099-1492(200011)13:7<384::aid-nbm655>3.0.co;2-v |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........b3a77cd516a392f52b7e6a7e00015c70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991492 09523480 |
|---|