Light-activated nitric-oxide overproduction theranostic nanoplatform based on long-circulating biomimetic nanoerythrocyte for enhanced cancer gas therapy
| العنوان: | Light-activated nitric-oxide overproduction theranostic nanoplatform based on long-circulating biomimetic nanoerythrocyte for enhanced cancer gas therapy |
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| المؤلفون: | Dong Ma, Wen-Bo Wang, Wei Xue, Jun Xu, Xiang Cai, Meng Wang, Xiaoyan Zhou, Xiang Wang, Cheng-Guang Wu, Jinglan Liang |
| المصدر: | Science China Chemistry. 64:1796-1810 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Hyperthermia, Tumor hypoxia, DNA damage, Chemistry, Cancer, General Chemistry, Photothermal therapy, medicine.disease, Nitric oxide, chemistry.chemical_compound, Membrane, In vivo, medicine, Biophysics |
| الوصف: | The limited intratumoral perfusion of nitric oxide (NO)-carrying nanoparticles into solid tumors caused by the inherent biological barriers in vivo greatly attenuates their generated efficacy. Herein, through entrapping heat-sensitive NO donors (BNN6) on mesoporous polydopamine nanoparticles (M-PDA) and subsequently enveloping with red blood cells membranes, a heat-responsive biomimetic theranostic nanoerythrocyte (M/B@R) is developed to boost NO-based cancer therapy. The reserved intact structure of red blood cells membranes (RBCm) endows M/B@R with superior biosafety and stealth properties for prolonged circulation time and subsequent enhanced tumor accumulation. Once internalized in tumors and excited by near-infrared light (NIR, 808 nm) irradiation, M/B@R can not only yield plenty of heat for photothermal therapy (PTT) but also achieve the overproduction of NO for highly-efficient NO gas therapy due to its high loading capacity and NIR-absorbing property of M-PDA. The generated NO further ensures the formation of ONOO− which possesses remarkable toxicity to tumor as well as alleviating tumor hypoxia. It is found that M/B@R with NIR as the excitation source can significantly induce synthetic lethality to tumors via the hyperthermia, DNA damage and the ease of tumor hypoxia. Simultaneously, M/B@R also exhibits the potential for bimodal fluorescence and photothermal imaging. The RBCm-camouflaged NO delivery nanoplatform with bimodal imaging capability in this work may provide a new combinatorial paradigm to induce PTT/NO for cancer theranostic applications. |
| تدمد: | 1869-1870 1674-7291 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b44e2e7b802bbc4707494f17f2e4661a https://doi.org/10.1007/s11426-021-1045-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........b44e2e7b802bbc4707494f17f2e4661a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18691870 16747291 |
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