Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus
| العنوان: | Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus |
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| المؤلفون: | Eman A. Awad, Magda A. Torky, Rania M. Bassiouny, Abeer M. Khattab, Rasha R. Elzehery, Rania M. Elhelaly |
| المصدر: | Eye. 37:1602-1607 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Ophthalmology |
| الوصف: | Objectives To detect the serum level of thyroid hormones, vitamin D and vitamin D receptors (VDR) polymorphism in keratoconus (KC) patients and to identify the association between vitamin D deficiency and thyroid dysfunction in KC. Methods This cross sectional study included 177 KC patients with no thyroid disorders compared to 85 healthy controls with normal corneal tomography. Measurements of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4) and serum 25-OH vitamin D were done using Enzyme linked immusoassay (ELISA test). VDR polymorphisms were tested including [Taq I (rs731236), Apa I (rs7975232) and Bsm I (rs1544410)] using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results An increase in frequency of thyroid disorders (P = 0.04), decrease in serum 25(OH) vitamin D level (P P P P P Conclusions Both thyroid disorders and low vitamin D are potential factors for KC development. Studying VDR at the molecular level provides interesting avenues for future research toward the identification of new KC cases. |
| تدمد: | 1476-5454 0950-222X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b473530ee266dc6ec2d7f71e8161413a https://doi.org/10.1038/s41433-022-02172-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b473530ee266dc6ec2d7f71e8161413a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765454 0950222X |
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