New compounds for the treatment of eczematous skin diseases
| العنوان: | New compounds for the treatment of eczematous skin diseases |
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| المؤلفون: | Hae-Hyuk Lee, Margitta Worm |
| المصدر: | Expert Opinion on Therapeutic Patents. 14:1257-1271 |
| بيانات النشر: | Informa Healthcare, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, integumentary system, biology, Erythema, business.industry, medicine.medical_treatment, Lichenification, Inflammation, General Medicine, Atopic dermatitis, medicine.disease, Immunoglobulin E, Dermatology, Cytokine, Drug Discovery, Immunology, biology.protein, Medicine, medicine.symptom, business, Contact dermatitis, Allergic contact dermatitis |
| الوصف: | Eczematous skin diseases such as atopic dermatitis and allergic contact dermatitis are common and are characterised by the appearance of oozing, erythema, crusting, papules and, in long standing lesions, lichenification. After the successful introduction of the topical immunomodulators as a new topical therapy of atopic eczema, several other therapeutic compounds have been developed in the last 2 years. These are presented in this article based on recent patents. Primarily, developments for the treatment of pruritus and inflammation are molecules affecting the H4-receptor, the cannabinoid receptors and the prostanoid receptors, but antagonists targeting PDE4, CCR-1 or -3, or chemoattractants have also been developed. The latest patents on glucocorticosteroids and their compositions are discussed, also, the antibody-derived and cytokine-targeted therapeutical agents. In the latter case, however, the number of patents has decreased due to their time-consuming and cost-intensive production. Furthermore, one ... |
| تدمد: | 1744-7674 1354-3776 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b5c4799eed7fc57ba16f6845996af77b https://doi.org/10.1517/13543776.14.9.1257 |
| رقم الأكسشن: | edsair.doi...........b5c4799eed7fc57ba16f6845996af77b |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17447674 13543776 |
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