Azadirachta indica (A. Juss.) and Curcuma longa (L.) modulate immunoglobulin and cytokine levels in Plasmodium berghei-infected mice
| العنوان: | Azadirachta indica (A. Juss.) and Curcuma longa (L.) modulate immunoglobulin and cytokine levels in Plasmodium berghei-infected mice |
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| المؤلفون: | Olufunso O. Olorunsogo, John Oludele Olanlokun |
| المصدر: | Comparative Clinical Pathology. 30:871-880 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biology, Parasitemia, Pharmacology, Azadirachta, biology.organism_classification, medicine.disease, Pathology and Forensic Medicine, Blood serum, Immunoglobulin M, Chloroquine, parasitic diseases, biology.protein, medicine, Plasmodium berghei, Anatomy, Curcuma, Interleukin 6, medicine.drug |
| الوصف: | Plasmodium infection causes inflammation in the host. A combination of herbs like Azadirachta indica and Curcuma longa may have beneficial effect in remediating inflammation in malaria disease. The aim of this study is to investigate the immunomodulatory and synergistic effects of the association of Azadirachta indica and Curcuma longa in experimental Plasmodium berghei infection. Fifty male Swiss mice were infected with chloroquine susceptible (NK 65) strain of Plasmodium berghei intraperitoneally. Parasitemia was confirmed using microscopy and the animals were grouped (n = 5), treated once daily and orally for 7 days with 200 and 400 mg/kg of A. indica and C. longa methanol extracts. Four hundred milligrams per kilogram A. indica was combined with the two doses of C. longa methanol extract and fractions. Negative control was treated with 10 mL/kg 5% (v/v) dimethyl sulfoxide (DMSO, vehicle) while positive control was treated with artemether–lumefantrine (10 mg/kg) and normal control not infected with parasites was treated with distilled water only. Animals were sacrificed on day 7, and blood serum was obtained. Serum immunoglobulins G (IgG) and immunoglobulin M (IgM), C-reactive protein (CRP), tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) were assayed using ELISA techniques. Combination of A. indica and C. longa significantly increased (P |
| تدمد: | 1618-565X 1618-5641 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b611be8746845ef81826d1e5d7684a70 https://doi.org/10.1007/s00580-021-03272-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........b611be8746845ef81826d1e5d7684a70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1618565X 16185641 |
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