Structural markers in prostate cancer serum imaged ex vivo using cryogenic transmission electron microscopy
| العنوان: | Structural markers in prostate cancer serum imaged ex vivo using cryogenic transmission electron microscopy |
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| المؤلفون: | Arijit Bose, Chris Thanos, Ashish K. Jha, Riyaz Basha, Nazneen Aziz |
| المصدر: | Journal of Electron Microscopy. 59:451-456 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Prostate cancer, Pathology, medicine.medical_specialty, Transmission electron microscopy, Healthy individuals, medicine, Biology, medicine.disease, Instrumentation, Ex vivo |
| الوصف: | We used cryogenic transmission electron microscopy (cryo-TEM) to identify differences in macromolecular structures present in the serum from healthy individuals (HI) and prostate cancer (PCa) patients and show that these differences are potential markers for disease. Using a murine orthotopic model of human PCa, we determined that some of these structural markers in serum are associated with the tumour burden. These findings signify the potential of this nanoscale ex vivo imaging technology of body fluids as a platform for discovering early markers of PCa and other diseases. |
| تدمد: | 1477-9986 0022-0744 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b65e79bbe049a252659114e64cc44fbf https://doi.org/10.1093/jmicro/dfq019 |
| رقم الأكسشن: | edsair.doi...........b65e79bbe049a252659114e64cc44fbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779986 00220744 |
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