Correlation of Calculated Vancomycin Trough Concentrations and Exposure: A Monte Carlo Simulation
العنوان: | Correlation of Calculated Vancomycin Trough Concentrations and Exposure: A Monte Carlo Simulation |
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المؤلفون: | Hans Haag, Anthony Lau |
المصدر: | Annals of Pharmacotherapy. :106002802311605 |
بيانات النشر: | SAGE Publications, 2023. |
سنة النشر: | 2023 |
مصطلحات موضوعية: | Pharmacology (medical) |
الوصف: | Background: Current recommendations are to dose vancomycin to target 24-hour area under the curve (AUC) of 400-600 mg·h/L to optimize efficacy and safety. Limited data support AUC monitoring, and some centers continue to use trough concentrations. A target of 10-20 mg/L has been proposed to reduce nephrotoxicity risk. Objective: To use previously published pharmacokinetic equations in a Monte Carlo simulation relating AUC exposure to trough concentrations when targeting an AUC between 400 and 600 mg·h/L. Methods: Previously published pharmacokinetic data were used as input parameters for a Monte Carlo simulation using previously published formulae to correlate AUC to simulated trough concentrations. Pharmacokinetic parameters were assumed to occur in a normal distribution pattern. We excluded irrelevant simulated cases. Maintenance doses of 15 mg/kg were rounded to the nearest 250 mg. Calculated trough concentrations for AUCs of both 400 and 600 mg·h/L were evaluated in each simulation. Results: A total of 10 000 Monte Carlo simulations were performed. Targeting an AUC of 400 mg·h/L resulted in a mean trough concentration of 10.3 ± 0.8 mg/L. Targeting an AUC of 600 mg·h/L resulted in a mean trough concentration of 15.4 ± 1.2 mg/L. Conclusion and Relevance: We demonstrate that a lower trough concentration range may be supported by an AUC of 400-600 mg·h/L, which may reduce risk and rates of nephrotoxicity without compromising previously established efficacious target trough concentrations. |
تدمد: | 1542-6270 1060-0280 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b66de65f5efef662f4356f7a383f7d0f https://doi.org/10.1177/10600280231160571 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi...........b66de65f5efef662f4356f7a383f7d0f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15426270 10600280 |
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