Plasma von Willebrand Factor in Patients with Acute Myocardial Infarction
| العنوان: | Plasma von Willebrand Factor in Patients with Acute Myocardial Infarction |
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| المؤلفون: | Miyuki Ono, Shunnosuke Handa, Naoto Aoki, Shinya Goto, Yuichi Fusegawa, Hiroyuki Sakai, Mami Goto |
| المصدر: | Japanese Journal of Thrombosis and Hemostasis. 9:64-70 |
| بيانات النشر: | Japanese Society on Thrombosis and Hemostasis, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, medicine.disease, Thrombophilia, Thrombosis, Coronary arteries, chemistry.chemical_compound, medicine.anatomical_structure, Coronary thrombosis, chemistry, Von Willebrand factor, hemic and lymphatic diseases, Plasminogen activator inhibitor-1, Internal medicine, cardiovascular system, Cardiology, medicine, biology.protein, Platelet, Myocardial infarction, business, circulatory and respiratory physiology |
| الوصف: | Acute myocardial infarction is known to be caused by thrombotic occlusion of coronary arteries. Although several investigators have suggested the abnormalities of plasma hemostatic parameters in patients with myocardial infarction, the relationship between these events and the onset of coronary thrombosis is still unclear. Recent in vitro investigations suggest the importance of the interaction between plasma ligand protein, von Willebrand factor (vWF), and platelet glycoproteins in the onset of arterial thrombosis, which occurs under the high shear stress of blood flow. In the present study, we investigated hemostatic abnormalities in patients with acute myocardial infarction by measuring plasma indicators including thrombin antithrombin III complex (TAT), plasminogen activator inhibitor 1 (PAI-1), the antigen level and ristocetin cofactor activities of vWF, and multimer analysis of vWF. In addition to hypercoagulabilities and increased antithrombolytic activities, a significant increase in antigen level or ristocetin cofactor activity of vWF was observed in patients with acute myocardial infarction. Although further study is needed, the increased levels of vWF in acute myocardial infarction may contribute to the re-occlusion of coronary artery after reperfusion treatment. |
| تدمد: | 1880-8808 0915-7441 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b67556f8a9380683de2002d99416a751 https://doi.org/10.2491/jjsth.9.64 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b67556f8a9380683de2002d99416a751 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18808808 09157441 |
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