Immunomodulation for unexplained recurrent implantation failure: where are we now?
العنوان: | Immunomodulation for unexplained recurrent implantation failure: where are we now? |
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المؤلفون: | Geneviève Genest, Shorooq Banjar, Walaa Almasri, Coralie Beauchamp, Joanne Benoit, William Buckett, Frederick Dzineku, Phil Gold, Michael H Dahan, Wael Jamal, Isaac Jacques Kadoch, Einav Kadour-Peero, Louise Lapensée, Pierre Miron, Talya Shaulov, Camille Sylvestre, Togas Tulandi, Bruce D Mazer, Carl A Laskin, Neal Mahutte |
المصدر: | Reproduction. 165:R39-R60 |
بيانات النشر: | Bioscientifica, 2023. |
سنة النشر: | 2023 |
مصطلحات موضوعية: | Embryology, Endocrinology, Reproductive Medicine, Obstetrics and Gynecology, Cell Biology |
الوصف: | In brief Immune dysfunction may contribute to or cause recurrent implantation failure. This article summarizes normal and pathologic immune responses at implantation and critically appraises currently used immunomodulatory therapies. Abstract Recurrent implantation failure (RIF) may be defined as the absence of pregnancy despite the transfer of ≥3 good-quality blastocysts and is unexplained in up to 50% of cases. There are currently no effective treatments for patients with unexplained RIF. Since the maternal immune system is intricately involved in mediating endometrial receptivity and embryo implantation, both insufficient and excessive endometrial inflammatory responses during the window of implantation are proposed to lead to implantation failure. Recent strategies to improve conception rates in RIF patients have focused on modulating maternal immune responses at implantation, through either promoting or suppressing inflammation. Unfortunately, there are no validated, readily available diagnostic tests to confirm immune-mediated RIF. As such, immune therapies are often started empirically without robust evidence as to their efficacy. Like other chronic diseases, patient selection for immunomodulatory therapy is crucial, and personalized medicine for RIF patients is emerging. As the literature on the subject is heterogenous and rapidly evolving, we aim to summarize the potential efficacy, mechanisms of actions and side effects of select therapies for the practicing clinician. |
تدمد: | 1741-7899 1470-1626 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b7507b663ead6bcc7bf38a5d89ccef69 https://doi.org/10.1530/rep-22-0150 |
رقم الأكسشن: | edsair.doi...........b7507b663ead6bcc7bf38a5d89ccef69 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 17417899 14701626 |
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