Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
| العنوان: | Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity |
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| المؤلفون: | Eric Dec, James Clement, Kaiyang Cheng, George M. Church, Michael B. Fossel, David H. Rehkopf, Luis Rosero-Bixby, Michael S. Kobor, David TS. Lin, Ake T. Lu, Zhe Fei, Wei Guo, Yap Ching Chew, Xiaojing Yang, Sulistyo E. Dwi Putra, Alex P. Reiner, Adolfo Correa, Adrian Vilalta, Chiara Pirazzini, Giuseppe Passarino, Daniela Monti, Beatrice Arosio, Paolo Garagnani, Claudio Franceschi, Steve Horvath |
| المصدر: | GeroScience. |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Aging, Geriatrics and Gerontology |
| الوصف: | Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age. |
| تدمد: | 2509-2723 2509-2715 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b88378c25a82c93dff6a68de5cbeceda https://doi.org/10.1007/s11357-023-00731-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b88378c25a82c93dff6a68de5cbeceda |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 25092723 25092715 |
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