Therapy With Allogeneic Severe Acute Respiratory Syndrome Coronavirus-2–Specific T Cells for Persistent Coronavirus Disease 2019 (COVID-19) in Immunocompromised Patients
| العنوان: | Therapy With Allogeneic Severe Acute Respiratory Syndrome Coronavirus-2–Specific T Cells for Persistent Coronavirus Disease 2019 (COVID-19) in Immunocompromised Patients |
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| المؤلفون: | Ghady Haidar, Jana L Jacobs, Kailey Hughes Kramer, Asma Naqvi, Amy Heaps, Urvi Parikh, Kevin D McCormick, Michele D Sobolewski, Mounzer Agha, Tatiana Bogdanovich, Vasilii Bushunow, Rafic Farah, Matthew Hensley, Yen-Michael S Hsu, Bruce Johnson, Cynthia Klamar-Blain, Jennifer Kozar, Elizabeth Lendermon, Bernard J C Macatangay, Christopher C Marino, Anastasios Raptis, Erin Salese, Fernanda P Silveira, Ann M Leen, William L Marshall, Michael Miller, Badrish Patel, Ercem Atillasoy, John W Mellors |
| المصدر: | Clinical Infectious Diseases. |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Microbiology (medical), Infectious Diseases |
| الوصف: | We administered severe acute respiratory syndrome coronavirus-2 viral-specific T cells (VSTs) under emergency investigational new drug applications to 6 immunocompromised patients with persistent coronavirus disease 2019 (COVID-19) and characterized clinical and virologic responses. Three patients had partial responses after failing other therapies but then died. Two patients completely recovered, but the role of VSTs in recovery was unclear due to concomitant use of other antivirals. One patient had not responded to 2 courses of remdesivir and experienced sustained recovery after VST administration. The use of VSTs in immunocompromised patients with persistent COVID-19 requires further study. |
| تدمد: | 1537-6591 1058-4838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b926026e57813c0c99f74dbb00c58cf7 https://doi.org/10.1093/cid/ciad233 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b926026e57813c0c99f74dbb00c58cf7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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