Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and X rays
| العنوان: | Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and X rays |
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| المؤلفون: | P. Ketelbant-Balasse, Jacqueline Flament-Durand, R. Maurus, R. Regnier, M. Spehl |
| المصدر: | Cancer. 35:319-325 |
| بيانات النشر: | Wiley, 1975. |
| سنة النشر: | 1975 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Cerebral calcification, medicine.diagnostic_test, business.industry, Brain biopsy, Unconsciousness, medicine.disease, Leukemia, Oncology, Acute lymphocytic leukemia, Cerebellar cortex, Medicine, Methotrexate, medicine.symptom, business, Complication, medicine.drug |
| الوصف: | The authors present the case of a child aged 7 years who suffered from relapsing acute lymphocytic leukemia. Treatment consisting mainly of oral and intrathecal methotrexate and x-ray therapy produced remission of the hematologic symptoms. Three years after the onset of the leukemia, mental deterioration gradually appeared. Radiography of the skull revealed diffuse bilateral calcium deposits in both cerebral and cerebellar hemispheres. Four years after the onset of the disease, a hematologic relapse occurred. Behavioral disorders became more severe and the child died after a period of seizures and unconsciousness. The main pathologic data obtained by the study of a brain biopsy and after a complete postmortem examination consisted of calcifications located bilaterally in the cerebral and cerebellar cortex. No signs of leukemia were present. Cerebral calcification is an extremely rare complication in the course of the therapy of lymphocytic leukemia. Its possible causes are discussed. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b991885d172f2e4dd024f92202c2a083 https://doi.org/10.1002/1097-0142(197502)35:2<319::aid-cncr2820350205>3.0.co;2-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b991885d172f2e4dd024f92202c2a083 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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