Spontaneous Myeloblastic Leukemia in a Young SD Rat
| العنوان: | Spontaneous Myeloblastic Leukemia in a Young SD Rat |
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| المؤلفون: | Eiichi Okezaki, Takeo Shimo, Yasuji Aoki, Osamu Nagata, Akemi Saito, Junichi Katayama |
| المصدر: | Journal of Toxicologic Pathology. 13:123-126 |
| بيانات النشر: | Japanese Society of Toxicologic Pathology, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Spleen, Autopsy, Biology, Toxicology, medicine.disease, Pathology and Forensic Medicine, Haematopoiesis, medicine.anatomical_structure, medicine, Red pulp, Neoplasm, Immunohistochemistry, Bone marrow, Hemoglobin |
| الوصف: | A hematopoietic neoplasm was found in a 14-week-old male Sprague-Dawley (SD) rat. Blood smear examination revealed the existence of numerous blastic cells with large, round or oval nuclei, and scant pale cytoplasm containing no granules. At autopsy, the liver and spleen were markedly enlarged and the right femur showed swelling and hemorrahge. Histopathologically, neoplastic cells infiltrated diffusely in the bone marrow, liver, and spleen, and destroyed their normal architectures. In the bone marrow neoplastic cells invaded into the surrounding tissues, while in the spleen they proliferated from the red pulp. Immunohistochemically, neoplastic cells were positive for lysozyme, while they were negative for hemoglobin, ED-1, OX-7, OX-8, and OX-12. Based on these findings, the present neoplasm was diagnosed as myeloblastic leukemia. |
| تدمد: | 1881-915X 0914-9198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::b9df059ea5ce90d93c13892a4cd7a135 https://doi.org/10.1293/tox.13.123 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........b9df059ea5ce90d93c13892a4cd7a135 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1881915X 09149198 |
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