A number of simulations were performed using the CFAST zone fire model to predict the relative times at which smoke inhalation and heat exposure would result in incapacitation. Fires in three building types were modeled: a ranch house, a hotel, and an office building. Gas species yields and rates of heat release for these design fires were derived from a review of real-scale fire test data. The incapacitation equations were taken from draft 14 of ISO document 13571. Sublethal effects of smoke were deemed important when incapacitation from smoke inhalation occurred before harm from thermal effects occurred. Real-scale HCl yield data were incorporated as available; the modeling indicated that the yield would need to be 5 to 10 times higher for incapacitation from HCl to precede incapacitation from narcotic gases, including CO CO2, HCN and reduce O2.