Collagen-the Ultrastructural Element of the Bone Matrix
| العنوان: | Collagen-the Ultrastructural Element of the Bone Matrix |
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| المؤلفون: | Ovidiu Gabriel Bratu, Camelia Cristina Diaconu, Andra Caragheorgheopol, Andra Cocolos, Nicoleta Dumitru, Constantin Dumitrache, Tiberiu Paul Neagu, Adina Ghemigian |
| المصدر: | Revista de Chimie. 69:1706-1709 |
| بيانات النشر: | Revista de Chimie SRL, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | business.industry, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, General Chemistry, General Medicine, Bone matrix, 030204 cardiovascular system & hematology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Materials Chemistry, Ultrastructure, Biophysics, Medicine, 030211 gastroenterology & hepatology, General Pharmacology, Toxicology and Pharmaceutics, business |
| الوصف: | There is an increased interest and more studies highlight the fact that bone strength depends not only on bone tissue quantity, but also on its quality, which is characterized by the geometry and shape of bones, trabecular bone microarchitecture, mineral content, organic matrix and bone turnover. Fibrillar type I collagen is the major organic component of bone matrix, providing form and a stable template for mineralization. The biomedical importance of collagen as a biomaterial for medical and cosmetic purposes and the improvement of the molecular, cellular biology and analytical technologies, led to increasing interest in establishing the structure of this protein and in setting of the relationships between sequence, structure, and function. Bone collagen crosslinking chemistry and its molecular packing structure are considered to be distinct features. This unique post-translational modifications provide to the fibrillar collagen matrices properties such as tensile strength and viscoelasticity. Understanding the complex structure of bone type I collagen as well as the dynamic nature of bone tissues will help to manage new therapeutic approaches to bone diseases. |
| تدمد: | 2668-8212 0034-7752 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::bcd6764d01bf68ec3384b6f126bfee38 https://doi.org/10.37358/rc.18.7.6400 |
| رقم الأكسشن: | edsair.doi...........bcd6764d01bf68ec3384b6f126bfee38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26688212 00347752 |
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