التفاصيل البيبلوغرافية
| العنوان: |
Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults |
| المؤلفون: |
Sarah Hirsiger, Lutz Jäncke, Susan Mérillat, Vincent Koppelmans, Rachael D. Seidler |
| المصدر: |
Human Brain Mapping. 36:2352-2363 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Cerebellum, medicine.medical_specialty, Radiological and Ultrasound Technology, Cerebellar function, White matter, Grip strength, medicine.anatomical_structure, Physical medicine and rehabilitation, Neurology, Functional neuroimaging, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Anatomy, Primary motor cortex, Grip force, Psychology, Neuroscience, Tissue volume |
| الوصف: |
Objectives Functional neuroimaging and voxel-based morphometry studies have confirmed the important role of the cerebellum in motor behavior. However, little is known about the relationship between cerebellar gray (GMv) and white matter (WMv) volume and manual motor performance in aging individuals. This study aims to quantify the relationship between cerebellar tissue volume and manual motor performance. Experimental design To gain more insight into cerebellar function and how it relates to the role of the primary motor cortex (M1), we related cerebellar GMv, WMv, and M1v to manual motor performance in 217 healthy older individuals. Left and right cerebellar GMv and WMv, and M1v were obtained using FreeSurfer. The following motor measures were obtained: grip force, tapping speed, bimanual visuomotor coordination, and manual dexterity. Principal observations Significant positive relationships were observed between cerebellar GMv and WMv and grip strength, right cerebellar WMv and right-hand tapping speed, right cerebellar WMv and dexterity, M1v and grip strength, and right M1v and left-hand dexterity, though effect sizes were small. Conclusions Our results show that cerebellar GMv and WMv are differently associated with manual motor performance. These associations partly overlap with the brain-behavior associations between M1 and manual motor performance. Not all observed associations were lateralized (i.e., ipsilateral cerebellar and contralateral M1v associations with motor performance), which could point to age-related neural dedifferentiation. The current study provides new insights in the role of the cerebellum in manual motor performance. In consideration of the small effect sizes replication studies are needed to validate these results. Hum Brain Mapp 36:2352–2363, 2015. © 2015 Wiley Periodicals, Inc. |
| تدمد: |
1065-9471 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf21dd89ed335585c76f75d51349a1b
https://doi.org/10.1002/hbm.22775 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........bcf21dd89ed335585c76f75d51349a1b |
| قاعدة البيانات: |
OpenAIRE |
