| الوصف: |
Background Globally, Liver hepatocellular carcinoma (LIHC) is among the most commonly reported cancer type. Despite numerous reports and efforts of this condition, its pathogenesis remains incompletely clear. Methods To search for candidate genes that play a role in LIHC carcinogenesis and progression, we analyzed LncRNA AC008622.2 mRNA expression using LIHC data from The Cancer Genome Atlas (TCGA). A chi-square (χ2) test was performed to assess relationships of AC008622.2 mRNA expressions and clinic-pathological characteristics. The diagnostic value of AC008622.2 for LIHC was generated by the receiver operating characteristic (ROC) curve assessment. Cox regression and Kaplan–Meier analyses were analyzed to determine the prognostic significance of AC008622.2 for LIHC outcomes. Interactions between AC008622.2 cells and infiltrated immune cells were analysed via ESTIMATE. Furthermore, a compound-target-lncRNA network was constructed from the TCMSP database. Results AC008622.2 mRNA expressions in LIHC tissues were elevated. AC008622.2 demonstrated specific value in LIHC diagnosis. High AC008622.2 levels correlated with histologicalal grade, clinical stage, and T classification of LIHC. Elevated AC008622.2 mRNA levels were associated with worse overall survival, and poor progression-free interval. Furthermore, attest to univariate analysis, AC008622.2 was established to be an independent risk factor for LIHC development. Additionally, there were significantly positive correlations between AC008622.2 expression and infiltrating immune cells, such as NK cells, neutrophils, DCs, cytotoxic cells, CD8 + T cells as well as B cells. Furthermore, a visualization network was constructed and suggested that AC008622.2 has 9 overlapping target genes with Danzhi Xiaoyao Powder. Conclusions AC008622.2 is a potential diagnostic as well as prognostic marker for LIHC. |
