Involvement of Lipoprotein(a) in calcification of coronary arteries and thoracic aorta as detected by X-ray computed tomography
| العنوان: | Involvement of Lipoprotein(a) in calcification of coronary arteries and thoracic aorta as detected by X-ray computed tomography |
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| المؤلفون: | Eiji Tamiya, Yoshiyuki Hada, Ryoji Kishi, Hiroshi Ikenouchi, Kazuro Sugishita, Nobuhiko Ito |
| المصدر: | International Journal of Angiology. 4:218-223 |
| بيانات النشر: | Georg Thieme Verlag KG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Aortic arch, medicine.medical_specialty, Aorta, biology, business.industry, valvular heart disease, Lipoprotein(a), Chest pain, medicine.disease, Coronary arteries, medicine.anatomical_structure, Internal medicine, medicine.artery, medicine, biology.protein, Cardiology, Thoracic aorta, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Calcification |
| الوصف: | The authors compared the severity of coronary calcification and thoracic aortic calcification as detected by x-ray computed tomography (X-ray CT) with Lipoprotein(a) [Lp(a)], and investigated whether Lp(a) is more important than total cholesterol (TC) or HDL-cholesterol (HDLC) as a risk factor for arteriosclerosis. Subjects were 64 patients (47 males, mean age 57.1±8.4 years) comprising 43 cases of ischemic heart disease, 9 cases of chest pain syndrome, 7 of valvular heart disease, and 5 of dilated cardiomyopathy. Fasted blood samples were collected early in the morning and values before medication were used. Lp(a) was measured by ELISA. Evaluation of coronary calcification by X-ray CT was performed in accordance with the procedure described in the authors' previous reports. Coronary calcification was assessed in all slices (slice thickness: 1 cm; scoring system: no coronary calcification, 0 points; coronary calcification less than 1 cm in length, 1 point; 1–2 cm, 2 points; over 2 cm, 3 points). The total score was used as coronary calcification score. For the aortic calcification score, the total number of aorta (slice thickness: 1 cm) with calcification from the superior margin of the aortic arch to the inferior cardiac margin was used. Mean scores of coronary and aortic calcification were 6.1±7.9 and 4.5±5.2 points, and Lp(a), TC, and HDLC, 23.7±23.3, 213±37, and 49.9±15.1 mg/dl, respectively. No correlation was seen between the scores of both coronary calcification and aortic calcification and any of the three lipid parameters, but for cases without coronary calcification, Lp(a) (10.6±8.5 mg/dl) was significantly lower (p |
| تدمد: | 1615-5939 1061-1711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::bea5ee1f71fb88c24f9b5ec1979c99a6 https://doi.org/10.1007/bf02042924 |
| رقم الأكسشن: | edsair.doi...........bea5ee1f71fb88c24f9b5ec1979c99a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16155939 10611711 |
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