Arenicolins: C-Glycosylated Depsides from Penicillium arenicola
| العنوان: | Arenicolins: C-Glycosylated Depsides from Penicillium arenicola |
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| المؤلفون: | Ali Azhdarinia, James B. Gloer, Servando Hernandez Vargas, Solmaz AghaAmiri, Cody E. Earp, Gerald F. Bills, Bruno Perlatti, Nan Lan |
| المصدر: | Journal of Natural Products. 83:668-674 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, Strain (chemistry), 010405 organic chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Side chain, Molecular Medicine, Moiety, Penicillium arenicola, Secondary metabolism, Cytotoxicity, Alkyl, Depside |
| الوصف: | During investigation of the secondary metabolism of four strains of Penicillium arenicola, two new depsides, arenicolins A (1) and B (2), were isolated and characterized. Their structures were established mainly by analysis of NMR and HRMS data and by comparison with known compounds. These depsides incorporate intriguing structural features, including dual alkyl side chains and a C-glycosyl unit, with 1 also containing an acylated 2-hydroxymethyl-4,5,6-trihydroxycyclohexenone moiety. Although the arenicolins were produced by all strains tested, arenicolin A (1) was obtained using only one of five medium compositions employed, while arenicolin B (2) was produced in all media tested. Neither compound showed antibacterial or antifungal activity, but 1 exhibited cytotoxicity toward mammalian cell lines, including colorectal carcinoma (HCT-116), neuroblastoma (IMR-32), and ductal carcinoma (BT-474), with IC50 values of 7.3, 6.0, and 9.7 μM, respectively. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::bec6552b3f475ac3fee452135f3a8ce0 https://doi.org/10.1021/acs.jnatprod.9b01099 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........bec6552b3f475ac3fee452135f3a8ce0 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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