Survivin Expression in Metastatic and Nonmetastatic Oral Squamous Cell Carcinoma: A Comparative Study
| العنوان: | Survivin Expression in Metastatic and Nonmetastatic Oral Squamous Cell Carcinoma: A Comparative Study |
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| المؤلفون: | R. Saranyan, B. Sekar, Madhavan R. Nirmal, M. Ambika, K. Indrapriyadharshini, Sathick Manzoor |
| المصدر: | Journal of Advanced Oral Research. 12:75-80 |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, stomatognathic diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Apoptosis, 030220 oncology & carcinogenesis, Survivin, Cancer research, Fetal tissue, Basal cell, Cell cycle, Biology |
| الوصف: | Aim: Survivin is a multifunctional protein chiefly involved in apoptosis and cell cycle regulation. Increased expression of survivin in tumors and fetal tissue determines its antiapoptotic activity. The aim of the study is to identify the immunoexpression of survivin in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and also to evaluate and compare the expression of survivin in metastatic and nonmetastatic OSCC of buccal mucosa. Materials and Methods: In total, 40 histopathologically proven cases of OSCC, including 20 metastatic and 20 nonmetastatic cases, are selected. Among the 20 metastatic and nonmetastatic cases, 10 well-differentiated and 10 moderately differentiated squamous cell carcinoma cases were included and were subjected to immunohistochemical staining for survivin expression. The results were analyzed by SPSS version 11.5 using chi-square test. Results: The expression of survivin in metastatic and nonmetastatic tumors is 15%–70% and 15%–60%, respectively. When comparing the cases of moderately differentiated squamous cell carcinoma in metastatic and nonmetastatic tumors, 70% cases show moderate staining intensity. Conclusion: The survivin expression was comparatively high in metastatic OSCC. Also based on the aforementioned results, survivin expression was high in increasing grades of OSCC. |
| تدمد: | 2320-2076 2320-2068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::bff3316159d829868b06d3229eff2b2e https://doi.org/10.1177/2320206820968448 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........bff3316159d829868b06d3229eff2b2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23202076 23202068 |
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