Naphthalene Exchange in [Re(η 6 ‐napht) 2 ] + with Pharmaceuticals Leads to Highly Functionalized Sandwich Complexes [M(η 6 ‐pharm) 2 ] + (M=Re/ 99m Tc)
| العنوان: | Naphthalene Exchange in [Re(η 6 ‐napht) 2 ] + with Pharmaceuticals Leads to Highly Functionalized Sandwich Complexes [M(η 6 ‐pharm) 2 ] + (M=Re/ 99m Tc) |
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| المؤلفون: | Olivier Blacque, Federica Battistin, Qaisar Nadeem, Roger Alberto |
| المصدر: | Chemistry – A European Journal. 28 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Organic Chemistry, chemistry.chemical_element, General Chemistry, Rhenium compounds, Rhenium, Medicinal chemistry, Catalysis, chemistry.chemical_compound, Sandwich type, Aniline, chemistry, Benzene, Naphthalene |
| الوصف: | Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction, which conditions are incompatible with most O- and N- functional groups. We report a new way for the synthesis of sandwich type complexes [Re(I· 6 -arene) 2 ] + and [Re(I· 6 -arene)(benzene)] + from [Re(I· 6 -napht) 2 ] + and [Re(I· 6 -napht)(benzene)] + , with functionalized arenes and pharmaceuticals. N-methylpyrrolidine (NMP) facilitates the substitution of naphthalene with the incoming arene. A series of fully characterized rhenium sandwich complexes with simple arenes, such as aniline, as well as with active compounds like lidocaine and melatonin are presented. With these rhenium compounds in hand, the radioactive sandwich complexes [ 99m Tc(I· 6 -pharm) 2 ] + (pharm = pharmaceutical) can be unambiguously confirmed. The direct labelling of pharmaceuticals with 99m Tc through I· 6 -coordination to phenyl rings and the confirmation of the structures with the rhenium homologues opens a path into molecular theranostics. |
| تدمد: | 1521-3765 0947-6539 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c13d709eac5c64a02783201432e68434 https://doi.org/10.1002/chem.202103566 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c13d709eac5c64a02783201432e68434 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213765 09476539 |
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