High-density lipoprotein lipid peroxidation in association with presence of coronary artery disease and atrial fibrillation in a large cross-sectional study
| العنوان: | High-density lipoprotein lipid peroxidation in association with presence of coronary artery disease and atrial fibrillation in a large cross-sectional study |
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| المؤلفون: | Timm H. Westhoff, Ivo Buschmann, Oliver Ritter, Theodoros Kelesidis, W Dammermann, P Hillmeister, Nikolaos Pagonas, R Mueller, B. Sasko, M Jaensch |
| المصدر: | European Heart Journal. 42 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Cross-sectional study, Atrial fibrillation, medicine.disease, Lipid peroxidation, Coronary artery disease, chemistry.chemical_compound, High-density lipoprotein, chemistry, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background The function of high-density lipoprotein (HDL) cholesterol may play a more important role in the prevention of cardiovascular disease compared to the concentration of the HDL. Cardiovascular diseases such as coronary artery disease (CAD) and atrial fibrillation (AF) have been linked to impaired HDL function. Purpose The aim of the present study is to assess a biochemical measure of the antioxidant function of HDL and its association with presence of CAD and AF. Methods Patients admitted for elective cardiac catheterization were recruited in this cross-sectional study. Out of 1231 participants that were included in the analyses, 727 patients had confirmed CAD (CAD group), 369 patients had no CAD (no CAD group) and 129 persons were included as a control group. HDL function was measured in sera by determination of HDL-lipid peroxidation content (HDLox) assessed by a validated fluorometric cell-free biochemical assay and was normalized for the levels of HDL cholesterol (normalized HDLox/HDL-C ratio or nHDLox; no units). Results are expressed as median with interquartile range. Associations of nHDLox with presence of CAD and AF were assessed by univariate and multivariate analyses. Results Participants in the CAD group had higher levels of nHDLox (0.80, 0.61–1.03) compared to the no CAD (0.70, 0.55–0.93) and control (0.66, 0.55–1.03, no units, p0.05) Conclusions Reduced antioxidant function of HDL (increased HDLox measured by a biochemical assay), a metric of HDL function, is increased in patients with atherosclerosis and manifested CAD and is also associated with the presence of atrial fibrillation independent of the presence of CAD. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Medical School of Brandenburg-MHB Fontane |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c1f373e667813183e130faf932b7746f https://doi.org/10.1093/eurheartj/ehab724.3433 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c1f373e667813183e130faf932b7746f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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