Comparison of 3 Protocols for Treatment after Induction of Remission in Dogs with Lymphoma
| العنوان: | Comparison of 3 Protocols for Treatment after Induction of Remission in Dogs with Lymphoma |
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| المؤلفون: | Cheryl E. Balkman, Hollis N. Erb, M. A. Kiselow, Blaise P. Burke, Andrea B. Flory, Margaret C. McEntee, Kenneth M. Rassnick, Karoliina Autio, Tracy L. Gieger |
| المصدر: | Journal of Veterinary Internal Medicine. 21:1364-1373 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Chemotherapy, medicine.medical_specialty, Vincristine, General Veterinary, Cyclophosphamide, business.industry, medicine.medical_treatment, Induction chemotherapy, Lomustine, CHOP, Procarbazine, Gastroenterology, Surgery, Prednisone, Internal medicine, medicine, business, medicine.drug |
| الوصف: | Background: The optimal treatment after inducing complete remission (CR) in dogs with lymphoma has not been established. Hypothesis: After inducing CR with L-asparaginase, vincristine, cyclophosphamide, doxorubicin, prednisone (L-CHOP); consolidation with either half-body radiation therapy (HBRT); or lomustine (CCNU) and mechlorethamine, vincristine, procarbazine, prednisone (MOPP) would improve first remission duration compared with continuing a CHOP-based protocol for an additional 4 months. Animals: Dogs with stage III-V lymphoma. Methods: Prospective clinical trial in which dogs initially were treated with an 8-week induction protocol that consisted of L-CHOP. Dogs in CR after induction were then allocated to 1 of 2 consolidation arms. A chemotherapy consolidation arm consisted of 2 treatments with CCNU and 1 cycle of MOPP. A HBRT arm consisted of 2 sequential 8.0-Gy fractions to the cranial and caudal half-body separated by 30 days. Vincristine was given between fractions. Results of the consolidation arms also were compared with a historical group treated with the same 8-week induction protocol followed by CHOP therapy until week 24. Results: Overall, 67% of the dogs were in CR after 8 weeks of induction chemotherapy and were compared. Fifty-two dogs were in the historical arm, 23 in the CCNU/MOPP arm, and 27 in the HBRT arm. No difference in first remission duration was found among groups. Median first remission duration for the historical, CCNU/MOPP, and HBRT arms were 307, 274, and 209 days, respectively (P= .28). Overall second CR rate was 82% and was not different among groups (all P > .58). Overall remission duration (P= .28) and survival time (P= .48) were not different among groups. Conclusions and Clinical Importance: Consolidation with either CCNU/MOPP or HBRT showed no advantage over a standard CHOP-based protocol. |
| تدمد: | 1939-1676 0891-6640 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c4bb3a73612117e28a8b76cb0724c0d0 https://doi.org/10.1111/j.1939-1676.2007.tb01960.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c4bb3a73612117e28a8b76cb0724c0d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19391676 08916640 |
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