Study of the oral hypoglycemic activity of Moringaoleifera leaves alone and in combination with Glibenclamide in streptozotocin induced diabetic albino rats
| العنوان: | Study of the oral hypoglycemic activity of Moringaoleifera leaves alone and in combination with Glibenclamide in streptozotocin induced diabetic albino rats |
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| المؤلفون: | Sushma V. Naidu, H L Kalabharathi, A M Satish, V H Pushpa, M K Jayanthi, R N Suresha |
| المصدر: | International Journal of Basic & Clinical Pharmacology. 6:2470 |
| بيانات النشر: | Medip Academy, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Glibenclamide, Oral hypoglycemic, business.industry, Medicine, Pharmacology, business, Streptozotocin, medicine.drug |
| الوصف: | Background: Oringaoleifera is a widely used plant with high medicinal value, well known for its pharmacological actions and is used in various conditions. It has been reported to have many biological properties like anti-inflammatory, antimicrobial, antispasmodic, antitumour including antidiabetic activity.Methods: The study was carried out in Wistar albino rats with body weight 150-250gms. Diabetes was induced by injecting Streptozotocin intraperitoneally- dose 55 mg/kg BW. Animals were divided into 5 groups with 6 animals in each group. First group (Control) was given 2% gum acacia. Other 4 groups were induced diabetes by giving Streptozotocin. Diabetic control group received gum acacia (0.5 ml), Standard group received Glibenclamide (0.5mg/kg BW), Test group received Moringaoleifera extract (300mg/kg) and Test+ Standard group receiving combination of Moringaoleifera and glibenclamide at half the above doses. All drugs were given orally for 28 days and blood glucose levels analyzed using Glucometer on Day 0 before drug and on D1, D3, D7, D14, D21, and D28. Data were statistically analyzed by ANOVA and Tukey‘s Post Hoc test.Results: Hypoglycemia produced by Moringaoleifera extract was significant (p |
| تدمد: | 2279-0780 2319-2003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c4d2bb1100676998c74132a208a785d3 https://doi.org/10.18203/2319-2003.ijbcp20174378 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c4d2bb1100676998c74132a208a785d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22790780 23192003 |
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