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Anti-inflammatory response of mannose-conjugated polyrotaxane endocytosed into macrophage

التفاصيل البيبلوغرافية
العنوان: Anti-inflammatory response of mannose-conjugated polyrotaxane endocytosed into macrophage
المؤلفون: Nobuhiko Yui, Tomo Ehashi, Hoon Hyun
المصدر: Macromolecular Research. 19:495-500
بيانات النشر: Springer Science and Business Media LLC, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Materials science, Polymers and Plastics, General Chemical Engineering, medicine.medical_treatment, Organic Chemistry, Polyacrylamide, Mannose, Conjugated system, Polyrotaxane, Endocytosis, Molecular biology, chemistry.chemical_compound, Cytokine, chemistry, Materials Chemistry, medicine, Macrophage, Mannan
الوصف: Macrophage response to mannose-conjugated polyrotaxane (Man-PRX) was examined in terms of the morphological changes in macrophage-like J774.1 cells and their inflammation-related cytokine expression. The results obtained were compared with those by mannose-conjugated α-CD (Man-CD), mannan, and mannose-conjugated polyacrylamide (Man-PAAm). The largest percentage of the morphological change was observed for Man-PRX, which is presumably induced by mannose receptor-mediated endocytosis. In the cytokine expression experiments, anti-inflammatory cytokine was expressed by Man-PRX but the pro-inflammatory cytokine level was increased by Man-PAAm. Therefore, Man-PRX has great potential as anti-inflammatory biomaterial.
تدمد: 2092-7673
1598-5032
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4e7b85aa2fa1a9e2a69f08b568e1d82
https://doi.org/10.1007/s13233-011-0506-8
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........c4e7b85aa2fa1a9e2a69f08b568e1d82
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20927673
15985032