RANDOMIZED CONTROLLED TRIAL OF ANTENATAL MAGNESIUM SULFATE FOR SHORT-TERM NEUROPROTECTION IN PREMATURE NEONATES
| العنوان: | RANDOMIZED CONTROLLED TRIAL OF ANTENATAL MAGNESIUM SULFATE FOR SHORT-TERM NEUROPROTECTION IN PREMATURE NEONATES |
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| المؤلفون: | Bindu Menon, Ajay Sankar, Prakash Manikoth, Anand M, Manoj Varanattu C |
| المصدر: | Indian Journal of Child Health. :199-202 |
| بيانات النشر: | Mansa STM Publishers, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, business.industry, Incidence (epidemiology), General Medicine, medicine.disease, Placebo, Confidence interval, law.invention, 03 medical and health sciences, 0302 clinical medicine, Intraventricular hemorrhage, Randomized controlled trial, law, 030225 pediatrics, Relative risk, medicine, Number needed to treat, Gestation, 030212 general & internal medicine, business |
| الوصف: | Objective: To test the hypothesis that antenatal magnesium sulfate (MgSO4) has a short term neuroprotective role in the early neonatal period, when given to women considered at risk for preterm delivery in a developing country. Study Design: Randomized, placebo-controlled, open label, trial. Participants: A total of 126 mothers who delivered at or below 34 weeks gestation were randomized to receive either antenatal MgSO4 (cases) or normal saline as placebo (controls). A total of 108 babies born were observed for the primary and secondary outcomes. Primary Outcome: The composite of the incidence of death and intraventricular hemorrhage (IVH) by cranial ultrasonography in surviving preterm infants. Results: There were 6 deaths in cases and 11 deaths in controls (relative risk [RR]: 0.54; 95% confidence interval [CI]: 0.2173-1.369; p=0.18). A statistically significant reduction in the number of IVH was observed in cases (n=1) compared to controls (n=9) (RR: 0.11; 95% CI: 0.0145-0.897; p=0.016) with a number needed to treat of 7. Conclusion: Antenatal MgSO4 resulted in a significant reduction in the risk of IVH in preterm infants born at or below 34 weeks of gestation. |
| تدمد: | 2349-6126 2349-6118 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c56034af9fc374c3a1168ba9dc911bd0 https://doi.org/10.32677/ijch.2017.v04.i02.020 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c56034af9fc374c3a1168ba9dc911bd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23496126 23496118 |
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