Effect of reversal of residual neuromuscular blockade on the amplitude of motor evoked potentials: a randomized controlled crossover study comparing sugammadex and placebo
| العنوان: | Effect of reversal of residual neuromuscular blockade on the amplitude of motor evoked potentials: a randomized controlled crossover study comparing sugammadex and placebo |
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| المؤلفون: | Kristina Cushman, Lashmi Venkatraghavan, Michael Dinsmore, Eric M. Massicotte, Sarah L Boyle, Nathan P Royan, Atul J. Prabhu, Nancy Lu |
| المصدر: | Neurological Sciences. 43:615-623 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Neuromuscular Blockade, medicine.medical_specialty, Neurology, business.industry, Interossei, Dermatology, General Medicine, medicine.disease, Placebo, Crossover study, Sugammadex, 03 medical and health sciences, Psychiatry and Mental health, Myelopathy, 0302 clinical medicine, medicine.anatomical_structure, Anesthesia, medicine, Mann–Whitney U test, 030212 general & internal medicine, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | To compare the amplitude changes in motor evoked potentials (MEP) with reversal of residual neuromuscular blockade using sugammadex or placebo in patients with cervical myelopathy. In this prospective randomized double-blind, placebo-controlled crossover trial, 38 patients with cervical myelopathy undergoing posterior cervical decompression and fusion were randomized to either sugammadex (2mg/kg) or placebo. The primary outcome measure was the increase in amplitude of the MEP in the first dorsal interossei (FDI) muscle at 3 min. Mann-Whitney U test was used to analyze the primary outcome measure. There was a significant increase in the amplitude of MEP at 3 min with sugammadex when compared to placebo group. The median (IQR) increase in MEP amplitude (μV) at 3 min from the left FDI in sugammadex and placebo group was 652.9 (142:1650) and 20.6 (−183.5:297.5) (p |
| تدمد: | 1590-3478 1590-1874 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c5f52497ffc16ab3b3b4463a1053dc04 https://doi.org/10.1007/s10072-021-05318-8 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........c5f52497ffc16ab3b3b4463a1053dc04 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15903478 15901874 |
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