Hypocholesterolemic effects ofCurcuma longaL. withNelumbo nuciferaleaf in anin vitromodel and a high cholesterol diet-induced hypercholesterolemic mouse model
| العنوان: | Hypocholesterolemic effects ofCurcuma longaL. withNelumbo nuciferaleaf in anin vitromodel and a high cholesterol diet-induced hypercholesterolemic mouse model |
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| المؤلفون: | Sun Young Lee, Ju-ryun Na, Ji-Ae Hong, Sunoh Kim, Yongjae Kim, Han Seul Hee, Myung-A Jung, Joon Yeol Lee |
| المصدر: | Animal Cells and Systems. 19:133-143 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Ethanol, biology, Lipid metabolism, Pharmacology, biology.organism_classification, General Biochemistry, Genetics and Molecular Biology, In vitro, chemistry.chemical_compound, chemistry, Oral administration, In vivo, Botany, lipids (amino acids, peptides, and proteins), Animal Science and Zoology, NELUMBO NUCIFERA LEAF, Curcuma, Lipoprotein |
| الوصف: | Hypercholesterolemia is one of the well-established risk factors for cardiovascular mortality and morbidity in coronary heart disease. The present study was designed to investigate the effects of different types of extracts (aqueous, 20%-, and 80% ethanol) of Nelumbo nucifera leaf (NL) and Curcuma Longa L. (CL) on hypercholesterolemia in in vitro and in vivo models. Our results in in vitro experiments showed that treatment with various extracts of both NL and CL dose-dependently inhibited lipid accumulation and total cholesterol content. The 20% ethanol extract of NL (NL20E) and the aqueous extract of CL (CLW) showed the highest activity. The in vivo experimental group was fed a high cholesterol diet (HCD) with oral administration of NL20E, CLW, or a mixture of NL20E with CLW (NC; mixed equal ratio) for 8 weeks. The oral administration of NL20E, CLW, and NC (100 or 300 mg/kg/day) resulted in the suppression of the levels of serum total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, liver lip... |
| تدمد: | 2151-2485 1976-8354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c765a7c56313afcb9223ec67f77d8444 https://doi.org/10.1080/19768354.2014.992953 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c765a7c56313afcb9223ec67f77d8444 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 21512485 19768354 |
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