Synthesis, Anti-inflammatory Activity and in silico Studies of Some Novel Morpholine Based Carboxamides
| العنوان: | Synthesis, Anti-inflammatory Activity and in silico Studies of Some Novel Morpholine Based Carboxamides |
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| المؤلفون: | Vasantha Kumar, Swamy Sreenivasa, Premanand M. Honavar, P. Nikhil, Naveen Kumar, P. Vishwanatha, Boja Poojary, B. Shivarama Holla |
| المصدر: | Asian Journal of Chemistry. 32:901-906 |
| بيانات النشر: | Asian Journal of Chemistry, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Biochemistry, 010405 organic chemistry, medicine.drug_class, Morpholine, In silico, medicine, General Chemistry, 01 natural sciences, Anti-inflammatory, 0104 chemical sciences |
| الوصف: | Two series of carboxamides were synthesized from 3-fluoro-4-morpholinoaniline and different substituted aromatic/heterocyclic carboxylic acids. All the compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized amide derivatives were screened for anti-inflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, compound 6e was found to be highly potent. Molecular docking interaction of active compounds revealed that effective binding was observed in the pocket of COX-I and COX-II proteins. |
| تدمد: | 0975-427X 0970-7077 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c79ca529da55d35e84b7bdd205293eb9 https://doi.org/10.14233/ajchem.2020.22488 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c79ca529da55d35e84b7bdd205293eb9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0975427X 09707077 |
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