Selective recognition of choline phosphate by tripodal hexa-urea receptors with dual binding sites: crystal and solution evidence
| العنوان: | Selective recognition of choline phosphate by tripodal hexa-urea receptors with dual binding sites: crystal and solution evidence |
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| المؤلفون: | Biao Wu, Wei Zuo, Yanxia Zhao, Chuandong Jia, Huizheng Zhang, Xiao-Juan Yang |
| المصدر: | Chemical Science. 10:2483-2488 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, General Chemistry, 010402 general chemistry, Phosphate, HEXA, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Enzyme, chemistry, Zwitterion, Urea, Choline, Ammonium, Binding site |
| الوصف: | Two tripodal hexa-urea receptors functionalized with aromatic terminal groups are capable of binding choline phosphate (CP). Crystal structures of the host-guest complexes reveal that the zwitterion CP is efficiently encapsulated in the tripodal hosts in a dual-site binding mode. The phosphate tail of CP is coordinated by the urea groups and the quaternary ammonium head is bound in a 'composite aromatic box' through cation-π and hydrogen-bonding interactions. Such a partial aromatic binding environment for the Me3N-+ cation mimics that of most enzymes catalyzing the conversion of quaternary ammonium substrates. Moreover, NMR, ESI-MS, and fluorescence studies demonstrate the selective binding and sensing of CP over other competing species such as ADP, ATP, choline and derivatives. |
| تدمد: | 2041-6539 2041-6520 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ca57f37c08de1cb7cb355cb4087f21f3 https://doi.org/10.1039/c8sc04338h |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........ca57f37c08de1cb7cb355cb4087f21f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20416539 20416520 |
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