Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B
| العنوان: | Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B |
|---|---|
| المؤلفون: | Elizabeth P. Merricks, Valder R. Arruda, Timothy C. Nichols, Natalie DeFriess, Katherine A. High, Paris Margaritis, Mark A. Kay, Helen W. G. Franck, Robin A. Raymer, Dwight A. Bellinger |
| المصدر: | Haemophilia. 16:19-23 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Factor replacement, business.industry, Haemophilia A, Gene transfer, Hematology, General Medicine, medicine.disease, Haemophilia, Gastroenterology, Surgery, Protein replacement therapy, hemic and lymphatic diseases, Internal medicine, Genotype, Coagulopathy, Medicine, Haemophilia B, business, Genetics (clinical) |
| الوصف: | Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe haemophilia. The phenotypic and genotypic characteristics of haemophilic dogs have been well-described, and such dogs are suitable for testing prophylactic protein replacement therapy and gene transfer strategies. In dogs with haemophilia, long-term effects on spontaneous bleeding frequency (measured over years) can be used as an efficacy endpoint in such studies. Although complete correction of coagulopathy has not been achieved, published data show that prophylactic factor replacement therapy and gene transfer can markedly reduce the frequency of spontaneous bleeding in haemophilic dogs. Further studies are currently ongoing. |
| تدمد: | 1365-2516 1351-8216 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cad0fdc7d598b80a35823e791a9ceb5d https://doi.org/10.1111/j.1365-2516.2010.02255.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........cad0fdc7d598b80a35823e791a9ceb5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652516 13518216 |
|---|