One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones
| العنوان: | One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones |
|---|---|
| المؤلفون: | Roman Doroschuk, Anzhelika I. Konovets, Sergey E. Pipko, Yurii S. Moroz, Andrey V. Bogolubsky, Andrey A. Tolmachev, Dmitriy M. Panov |
| المصدر: | Synthesis. 46:1765-1772 |
| بيانات النشر: | Georg Thieme Verlag KG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, Trimethylsilyl, Organic Chemistry, Condensation, Organic chemistry, Lewis acids and bases, Reductive amination, Carbonyl group, Catalysis, Scavenger (chemistry) |
| الوصف: | A combination of a condensation mixture [a Lewis acid, Ti(Oi-Pr)4, and a water scavenger, 1-(trimethylsilyl)-2-pyrrolidinone] and a simple reductant (NaBH4) provides an efficient one-pot approach to parallel synthesis of secondary amines by the reductive amination of ketones. The approach demonstrated its applicability to a variety of substrates with different degree of hindrance of an amino or a carbonyl group affording products in moderate to high yields. |
| تدمد: | 1437-210X 0039-7881 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cb4936851030615ac70bbf7449cf2dff https://doi.org/10.1055/s-0033-1341226 |
| رقم الأكسشن: | edsair.doi...........cb4936851030615ac70bbf7449cf2dff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
|---|