In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement
| العنوان: | In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement |
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| المؤلفون: | Liwei Liu, Yating Wang, Yue Zhao, Junle Qu, Zhen Yuan, Shaozhuang Yang |
| المصدر: | Applied Physics Letters. 113:143703 |
| بيانات النشر: | AIP Publishing, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Materials science, Physics and Astronomy (miscellaneous), Blood viscosity, Photoacoustic imaging in biomedicine, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Frequency spectrum, 010309 optics, Full width at half maximum, Viscosity, In vivo, 0103 physical sciences, Negative correlation, 0210 nano-technology, Biomedical engineering |
| الوصف: | In this letter, we proposed a photoacoustic (PA) method for noninvasively detecting blood viscosity in subcutaneous microvasculature with the frequency-resolved measurement. The influence of viscosity on PA generation was investigated theoretically, and a negative correlation was shown between the viscosity and the full width at half maximum (FWHM) of the PA frequency spectrum, which can be utilized to reflect the viscosity distribution. To test the feasibility and accuracy of this method, water mixed with different concentrations of glycerol was measured. FWHM of the PA frequency spectrum was also obtained in vivo in the mouse ear to characterize the blood viscosity from different vessel bifurcations, and the metabolism-induced viscosity changes were dynamically monitored in the microvasculature. Experimental results demonstrate that this technique has future potential clinical applications for real-time monitoring the viscosity changes in subcutaneous microvasculature. |
| تدمد: | 1077-3118 0003-6951 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::cf7809552532a3e43681382ae9d8279d https://doi.org/10.1063/1.5039538 |
| رقم الأكسشن: | edsair.doi...........cf7809552532a3e43681382ae9d8279d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Scitation. | تدمد: | 10773118 00036951 |
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