Abstract P1-09-06: A prospective longitudinal study of the impact of breast cancer treatment with adjuvant chemotherapy or tamoxifen alone on ovarian reserve
| العنوان: | Abstract P1-09-06: A prospective longitudinal study of the impact of breast cancer treatment with adjuvant chemotherapy or tamoxifen alone on ovarian reserve |
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| المؤلفون: | Maura N. Dickler, J. Quistorff, Fred Moy, Sumanta Goswami, Robert Stobezki, Clifford A. Hudis, Giuliano Bedoschi, Fernanda Pacheco, Eli Grunblatt, Mark E. Robson, Tessa Cigler, Sujata Patil, Kutluk Oktay, Shari Goldfarb |
| المصدر: | Cancer Research. 75:P1-09 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Gynecology, Cancer Research, Longitudinal study, medicine.medical_specialty, business.industry, media_common.quotation_subject, Cancer, Fertility, medicine.disease, Breast cancer, Oncology, Cohort, medicine, Fertility preservation, business, Ovarian reserve, Tamoxifen, media_common, medicine.drug |
| الوصف: | Background: Many women with breast cancer (BC) of reproductive age would prefer to preserve their fertility and ovarian function, if possible. However, available information is insufficient to predict the likelihood and extent of ovarian damage that will be suffered by an individual woman. In prior studies, menses was used as a surrogate for fertility, but it is a poor marker of future fertility. Preliminary work suggests that anti-mullerian hormone (AMH) may be a better surrogate for ovarian reserve. The goal of this study is to delineate the extent of ovarian damage from specific treatment regimens by using serum AMH. Here we report results from the largest longitudinal study with a pretreatment evaluation to measure the impact of both chemotherapy (chemo) and tamoxifen (tam) on ovarian reserve in BC patients. Methods: A multi-institutional longitudinal IRB-approved study was performed in 207 premenopausal women with stage 0-III BC. AMH levels were evaluated at baseline and 1 yr post completion of adjuvant chemo or 1 yr post initiation of tam. After the exclusions (failure to follow-up, sample inadequacy, presumed PCOS and consent withdrawal), 115 women ages 26-46 (median 38) were available for analysis at 1 yr post treatment (primary endpoint). AMH levels were measured in frozen sera with an in-house ultrasensitive ELISA assay and were log transformed due to non-normal distribution. Results were analyzed with Wilcoxon rank sum test and repeated measures ANOVA to adjust for age, tam use and stage. Results: In the 115 evaluable women, 98 pts had HR positive BC & 17 had triple negative BC. 77 pts received anthracycline-based (ddAC-T/EC-T) chemo, 26 non-anthracycline-based chemo (TC/CMF/TH) & 12 tam only. In the 103 women who received chemo, compared to baseline (median 0.21 ng/ml, 0.001-3.9 ng/ml), AMH levels declined significantly (median 0.11 ng/ml, 0.001-4.47 ng/ml; p Citation Format: Shari B Goldfarb, Giuliano Bedoschi, Eli Grunblatt, Sumanta Goswami, Tessa Cigler, Jessica Quistorff, Fernanda Pacheco, Robert Stobezki, Mark Robson, Fred Moy, Clifford Hudis, Sujata Patil, Maura Dickler, Kutluk Oktay. A prospective longitudinal study of the impact of breast cancer treatment with adjuvant chemotherapy or tamoxifen alone on ovarian reserve [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-09-06. |
| تدمد: | 1538-7445 0008-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d0c32adb610f4fa711933597c6691e63 https://doi.org/10.1158/1538-7445.sabcs14-p1-09-06 |
| رقم الأكسشن: | edsair.doi...........d0c32adb610f4fa711933597c6691e63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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