Synthesis and Antibacterial Evaluation of 5-{(E)-[4-(2',5'-Dioxo-2',5'-Dihydro-1h-Pyrrol-1-Yl)Phenyl]Diazenyl-2-Methyl-N3-Phenyl-3-Thiophenecarboxamide Analogues
| العنوان: | Synthesis and Antibacterial Evaluation of 5-{(E)-[4-(2',5'-Dioxo-2',5'-Dihydro-1h-Pyrrol-1-Yl)Phenyl]Diazenyl-2-Methyl-N3-Phenyl-3-Thiophenecarboxamide Analogues |
|---|---|
| المؤلفون: | Ella E.E, Iyun, Tajuddeen N, Musa H, Habila J.D |
| المصدر: | International Journal of Chemistry and Materials Research. 3:121-129 |
| بيانات النشر: | Conscientia Beam, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Minimum bactericidal concentration, Chemistry, Stereochemistry, medicine.disease_cause, Dilution, Ciprofloxacin, Minimum inhibitory concentration, Staphylococcus aureus, medicine, Agar diffusion test, Spectral data, Escherichia coli, Nuclear chemistry, medicine.drug |
| الوصف: | A series of thiophene-carboxamide analogues (1a-c) were synthesized by incorporating N-phenylmaleimide and 5-amino-4-substituted-(2,4-dimethylphenyl)-2-methyl-3-thiophenecarboxamide and their structures were assigned by studying their spectral data. The synthesised compounds were tested against Staphylococcus aureus and Escherichia coli using agar-in-well diffusion and broth micro dilution methods. The zone of inhibition values ranged from 20 24 mm against the two test organisms for all the compounds tested (1a-c). The result of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) showed that all the test compounds inhibited and completely killed S. aureus and E. coli at a concentration range of 0.63 2.50 µg/mL and .031 2.50 µg/mL respectively. The MBC value of compound 1a was the same as that of the standard drug (ciprofloxacin) used on E. coli (0.63 mg/mL) and S. aureus (0.25 µg/mL). |
| تدمد: | 2311-763X 2312-0991 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d10825af6ed1170da0c491de93f29b72 https://doi.org/10.18488/journal.64/2015.3.7/64.7.121.129 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d10825af6ed1170da0c491de93f29b72 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2311763X 23120991 |
|---|