Improving radiation dosimetry with an automated micronucleus scoring system: correction of automated scoring errors
| العنوان: | Improving radiation dosimetry with an automated micronucleus scoring system: correction of automated scoring errors |
|---|---|
| المؤلفون: | Younghyun Lee, Young Woo Jin, Ki Moon Seong, Ruth C. Wilkins, Seongjae Jang |
| المصدر: | Radiation and Environmental Biophysics. |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Radiation, Biophysics, General Environmental Science |
| الوصف: | Radiation dose estimations performed by automated counting of micronuclei (MN) have been studied for their utility for triage following large-scale radiological incidents; although speed is essential, it also is essential to estimate radiation doses as accurately as possible for long-term epidemiological follow-up. Our goal in this study was to evaluate and improve the performance of automated MN counting for biodosimetry using the cytokinesis-block micronucleus (CBMN) assay. We measured false detection rates and used them to improve the accuracy of dosimetry. The average false-positive rate for binucleated cells was 1.14%; average false-positive and -negative MN rates were 1.03% and 3.50%, respectively. Detection errors seemed to be correlated with radiation dose. Correction of errors by visual inspection of images used for automated counting, called the semi-automated and manual scoring method, increased accuracy of dose estimation. Our findings suggest that dose assessment of the automated MN scoring system can be improved by subsequent error correction, which could be useful for performing biodosimetry on large numbers of people rapidly, accurately, and efficiently. |
| تدمد: | 1432-2099 0301-634X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d120c5483e0fbe37b30fbf3604abe825 https://doi.org/10.1007/s00411-023-01030-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d120c5483e0fbe37b30fbf3604abe825 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322099 0301634X |
|---|