Metal-Free Halogenation of N-Substituted Enaminoesters and Enaminones: A Facile Access to Functionalized α,α-Dihaloimines
| العنوان: | Metal-Free Halogenation of N-Substituted Enaminoesters and Enaminones: A Facile Access to Functionalized α,α-Dihaloimines |
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| المؤلفون: | Changfu Qiu, Chunhua Wang, Tongchuan Suo, Songtao Bie, Zheng Li, Chuanjiang Qiu, He-Shui Yu, Fangyi Li |
| المصدر: | Synthesis. 52:1301-1314 |
| بيانات النشر: | Georg Thieme Verlag KG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Reaction conditions, General method, 010405 organic chemistry, Organic Chemistry, Halogenation, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Enamine, chemistry.chemical_compound, Transition metal, Safe operation, chemistry, Metal free |
| الوصف: | An efficient and general method for the synthesis of functionalized α,α-dihaloimines via halogenation of N-substituted enaminoesters and enaminones is described. This reaction, in which both α,α-dihaloimines and mixed α,α-dihaloimines could be achieved in good to excellent yields, is believed to proceed via an α-monohalogenated enamine intermediate. This synthetic method features no use of transition metals, readily accessible substrates, mild reaction conditions, simple and safe operation, and gram scale synthesis. Furthermore, the synthetic utility of the products was demonstrated by their efficient transformations to further useful nitrogen-containing heterocycles and building blocks. |
| تدمد: | 1437-210X 0039-7881 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d1a1dd421af28212fd10563eeef0fec2 https://doi.org/10.1055/s-0039-1690819 |
| رقم الأكسشن: | edsair.doi...........d1a1dd421af28212fd10563eeef0fec2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
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