التفاصيل البيبلوغرافية
| العنوان: |
Data from Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma, Favoring T-cell Infiltration and Tumor Control |
| المؤلفون: |
Jean-Pierre Abastado, Alessandra Nardin, Marie-Françoise Avril, Armelle Prévost-Blondel, Masashi Kato, Charles Mackay, Charlene Tow, Laure Loumagne, Caleb Huang, Anne-Laure Puaux, Michelle Hong |
| بيانات النشر: |
American Association for Cancer Research (AACR), 2023. |
| سنة النشر: |
2023 |
| الوصف: |
T-cell infiltration is known to impact tumor growth and is associated with cancer patient survival. However, the molecular cues that favor T-cell infiltration remain largely undefined. Here, using a genetically engineered mouse model of melanoma, we show that CXCR3 ligands and CCL5 synergize to attract effector T cells into cutaneous metastases, and their expression inhibits tumor growth. Treatment of tumor-bearing mice with chemotherapy induced intratumoral expression of these chemokines and favored T-cell infiltration into cutaneous tumors. In patients with melanoma, these chemokines were also upregulated in chemotherapy-sensitive lesions following chemotherapy, and correlated with T-cell infiltration, tumor control, and patient survival. We found that dacarbazine, temozolomide, and cisplatin induced expression of T-cell–attracting chemokines in several human melanoma cell lines in vitro. These data identify the induction of intratumoral expression of chemokines as a novel cell-extrinsic mechanism of action of chemotherapy that results in the recruitment of immune cells with antitumor activity. Therefore, identifying chemotherapeutic drugs able to induce the expression of T-cell–attracting chemokines in cancer cells may represent a novel strategy to improve the efficacy of cancer immunotherapy. Cancer Res; 71(22); 6997–7009. ©2011 AACR. |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::d1cb8dee4049b9b9117b2e735f263df5
https://doi.org/10.1158/0008-5472.c.6502868.v1 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........d1cb8dee4049b9b9117b2e735f263df5 |
| قاعدة البيانات: |
OpenAIRE |
