Clinical Study of the Intra-articular Injection of Arteparon for Osteoarthritis of the Knee Joint
| العنوان: | Clinical Study of the Intra-articular Injection of Arteparon for Osteoarthritis of the Knee Joint |
|---|---|
| المؤلفون: | Mikio Ogino, Naoichi Tsuyama, Kimio Moro, Tetsuya Hara, Torakichi Aoki, Hideo Yano, Ryuzoh Mikami, Eishin Chin, Hajime Inoue, Yasuyo Otani, Yoshihisa Akasaka, Tetsuo Suzuki, Hiroshi Takahashi, Norikazu Kuriya, Makoto Furuya |
| المصدر: | Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 12:39-50 |
| بيانات النشر: | Japanese Society of Clinical Pharmacology and Therapeutics, 1981. |
| سنة النشر: | 1981 |
| مصطلحات موضوعية: | Pharmacology, business.industry, medicine.medical_treatment, Osteoarthritis, Knee Joint, medicine.disease, Placebo, Clinical study, Intra articular, Anesthesia, Arthropathy, medicine, Pharmacology (medical), business, Saline, Hormone |
| الوصف: | The drug arteparon (mucopolysaccharide polysulfuric acid esters) was developed in West Germany and its effects have been reported by Dettmer, Greiling, Greiling and Stuhlsatz, Platt, and Binzus and Holzer. To test this drug, a double-blind clinical study was conducted by authors using saline as the control (placebo). Although a total of 72 patients were studied, an evaluation of the effects was made on 27 patients in the arteparon group and on 31 patients in the placebo group.It was found that the arteparon group was significantly superior to the placebo group-in terms of total effectiveness and usefulness. Arteparon was more effective than the placebo especially for the alleviation of pain specific to arthropathy of the knee. However, no other significant difference between either group was observed regarding other symptoms. Although the only drug now available for intraarticular injection for arthrosis deformans of the knee is adrenocortical hormones, this hormone causes serious adverse reactions. This study indicates that arteparon can be a useful drug for the treatment of arthropathy of the knee. |
| تدمد: | 1882-8272 0388-1601 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d1d3c13e2c9ac35ab34e869f0bf70dfa https://doi.org/10.3999/jscpt.12.39 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d1d3c13e2c9ac35ab34e869f0bf70dfa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18828272 03881601 |
|---|