Recent Advances in the Medicinal Chemistry of Liver X Receptors
| العنوان: | Recent Advances in the Medicinal Chemistry of Liver X Receptors |
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| المؤلفون: | Shaimaa S. Goher, Thomas P. Burris, Lamees Hegazy, Bahaa El-Dien M. El-Gendy, M. M. H. Arief |
| المصدر: | Journal of Medicinal Chemistry. 61:10935-10956 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, Chemistry, medicine.medical_treatment, Computational biology, Steroid, 03 medical and health sciences, 030104 developmental biology, Immune system, Nuclear receptor, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Retinoid, Liver X receptor, Receptor, Transcription factor |
| الوصف: | Nuclear hormone receptors represent a large family of ligand-activated transcription factors that include steroid receptors, thyroid/retinoid receptors, and orphan receptors. Among nuclear hormone receptors, the liver X receptors have emerged as very important drug targets. These receptors regulate some of the most important metabolic functions, and they were also identified as anti-inflammatory transcription factors and regulators of the immune system. The development of drugs targeting liver X receptors continues to be a challenge, but advances in our knowledge of receptor structure and function move us forward, toward achieving this goal. This review highlights the latest advances in the development of synthetic LXR modulators in the primary literature from 2013 to 2017. In this review, we place great emphasis on the structure and function of LXRs because of their essential role in the drug design process. The structure–activity relationships of the most active and promising synthetic modulators are di... |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d361ae9d65745cc9ddb032f0fece666c https://doi.org/10.1021/acs.jmedchem.8b00045 |
| رقم الأكسشن: | edsair.doi...........d361ae9d65745cc9ddb032f0fece666c |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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