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U-87947E, a protein quinolone antibacterial agent incorporating a bicyclo[1.1.1]pent-1-yl (BCP) subunit

التفاصيل البيبلوغرافية
العنوان: U-87947E, a protein quinolone antibacterial agent incorporating a bicyclo[1.1.1]pent-1-yl (BCP) subunit
المؤلفون: Raymond J. Reid, Gary E. Zurenko, Ronda D. Schaadt, Barbachyn Michael R, John W. Allison, Toops Dana S, Hutchinson Douglas K, Betty H. Yagi
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:671-676
بيانات النشر: Elsevier BV, 1993.
سنة النشر: 1993
مصطلحات موضوعية: Bicyclic molecule, Chemistry, medicine.drug_class, Stereochemistry, Aerobic bacteria, Protein subunit, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, A protein, Quinolone, medicine.disease_cause, Biochemistry, Ciprofloxacin, Staphylococcus aureus, Drug Discovery, medicine, Molecular Medicine, Molecular Biology, medicine.drug, Antibacterial agent
الوصف: Incorporation of a bicyclo[1.1.1]pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, U-87947E, exhibits enhanced activity relative to that of ciprofloxacin against gram-positive aerobic bacteria and anaerobic organisms. Time-kill kinetic studies reveal that U-87947E is exquisitely bactericidal against ciprofloxacin-resistant Staphylococcus aureus.
تدمد: 0960-894X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d473c3ab37e1a7576f9f4b87c210bbc6
https://doi.org/10.1016/s0960-894x(01)81251-8
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........d473c3ab37e1a7576f9f4b87c210bbc6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0960894X