Microglial Gi-dependent dynamics regulate brain network hyperexcitability
| العنوان: | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
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| المؤلفون: | Reuben Thomas, Terry Dean, Mark A. Petersen, Matthias G. Haberl, Jae K. Ryu, Victoria A. Rafalski, Andrew S. Mendiola, Eric A. Bushong, Keunyoung Kim, Daniel Naranjo Sampson, Elif G. Sozmen, Reshmi Tognatta, Rosa Meza Acevedo, Zhaoqi Yan, Shaun R. Coughlin, Mark H. Ellisman, Pamela E. Rios Coronado, Belinda S. Cabriga, Jorge J. Palop, Sophia Bardehle, Mario Merlini, Katerina Akassoglou, Matthew Madany, Keran Ma |
| المصدر: | Nature Neuroscience. 24:19-23 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Microglia, medicine.diagnostic_test, business.industry, General Neuroscience, Motility, Electroencephalography, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, nervous system, Pilocarpine, medicine, Biological neural network, Premovement neuronal activity, Signal transduction, business, Neuroscience, 030217 neurology & neurosurgery, medicine.drug, Calcium signaling |
| الوصف: | Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases. |
| تدمد: | 1546-1726 1097-6256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d558dcdacc49cb06330157f8ecf84e06 https://doi.org/10.1038/s41593-020-00756-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d558dcdacc49cb06330157f8ecf84e06 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461726 10976256 |
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