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Imaging Characteristics and Diagnostic Performance of 2-deoxy-2-[18F]fluoro-d-Glucose PET/CT for Melanoma Patients Who Demonstrate Hyperprogressive Disease When Treated with Immunotherapy

التفاصيل البيبلوغرافية
العنوان: Imaging Characteristics and Diagnostic Performance of 2-deoxy-2-[18F]fluoro-d-Glucose PET/CT for Melanoma Patients Who Demonstrate Hyperprogressive Disease When Treated with Immunotherapy
المؤلفون: Jarrett Rosenberg, Sunil Reddy, Judy Nguyen, Benjamin L. Franc, Valentina Ferri, Lisa C. Zaba, Andrei Iagaru, Farshad Moradi, Guido Davidzon, Carina Mari Aparici, Tomomi Nobashi, Ryusuke Nakamoto
المصدر: Molecular Imaging and Biology. 23:139-147
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 2 deoxy 2 18f fluoro d glucose, Cancer Research, PET-CT, business.industry, medicine.medical_treatment, Melanoma, Area under the curve, Disease, Metabolic tumor volume, Immunotherapy, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, medicine, Radiology, Nuclear Medicine and imaging, Tumor growth, Nuclear medicine, business
الوصف: We investigated the ability of baseline 2-deoxy-2-[18F]fluoro-d-glucose PET/CT parameters, acquired before the start of immunotherapy, to predict development of hyperprogressive disease (HPD) in melanoma patients. We also evaluated the diagnostic performances of ratios of baseline and first restaging PET/CT parameters to diagnose HPD without information of the tumor growth kinetic ratio (TGKR) that requires pre-baseline imaging before baseline imaging (3 timepoint imaging). Seventy-six patients who underwent PET/CT before and approximately 3 months following initiation of immunotherapy were included. PET/CT parameters, including metabolic tumor volume (MTV) for all melanoma lesions and total measured tumor burden (TMTB) based on irRECIST, were measured from baseline PET/CT (MTVbase and TMTBbase) and first restaging PET/CT (MTVpost and TMTBpost). The ratios of MTV (MTVpost/MTVbase, MTVr) and TMTB (TMTBpost/TMTBbase, TMTBr) were calculated. MTVbase of HPD patients (n = 9, TGKR ≥ 2) was larger than that of non-HPD (n = 67, TGKR
تدمد: 1860-2002
1536-1632
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d69a6cf58ede464fead5cea1acd067b6
https://doi.org/10.1007/s11307-020-01526-4
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........d69a6cf58ede464fead5cea1acd067b6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18602002
15361632