Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy

التفاصيل البيبلوغرافية
العنوان: Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
المؤلفون: E. Draeger, Christopher J Tien, Zhe Jay Chen, Daniel W Pinkham
المصدر: Brachytherapy. 20:401-409
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Surface brachytherapy, business.industry, Planning target volume, Imaging phantom, High-Dose Rate Brachytherapy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Increase dose, Oncology, 030220 oncology & carcinogenesis, Line (geometry), Medicine, Radiology, Nuclear Medicine and imaging, business, Radiation treatment planning, Rotation (mathematics), Biomedical engineering
الوصف: Purpose Multiple dwell positions (“multidwell”) within a Leipzig-style applicator can be used to increase dose uniformity and treatment area. Model-based dose calculation algorithms (MBDCAs) are necessary for accurate calculations involving these applicators because of their nonwater equivalency and complex geometry. The purpose of this work was to create template plans from MBDCA calculations and present their dwell times and positions for users of these applicators without access to MBDCAs. Methods and Materials The Leipzig-style solid applicator model within our treatment planning system was used to design template plans. Five template plans, normalized to 0.3 cm depth within a water phantom, were optimized using the treatment planning system MBDCA. Each template plan contained unique dwell positions, times, and active lengths (0.5–1.5 cm). A single-dwell distribution was optimized for comparison. The stem of this applicator stops within the shell; therefore, one template plan contained an intrafraction rotation to determine the largest dose distribution achievable. Effects of imperfect applicator rotation were quantified by inserting rotational offsets and comparing the V100%, D95%, and minimum dose coverage for planning target volumes created from 80%/90% isodose lines. Results The 90% (80%) isodose line dimensions at 0.3 cm depth for single-dwell increased from 0.94 × 0.97 (1.53 × 1.57) cm2 to 2.09 × 1.24 (2.75 × 1.88) cm2 in the largest template plan. Manually inserted angular offsets up to ±10° for the template plan requiring rotation preserved V100%, D95%, and minimum dose within 2.0%, 1.9%, and 8.0%, respectively. Conclusion A set of template plans was created to provide accessibility to the multidwell methodology, even for users without access to MBDCAs. Each template plan should be reviewed before clinical implementation.
تدمد: 1538-4721
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6a83b5984b846909192aa410393ca48
https://doi.org/10.1016/j.brachy.2020.09.019
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........d6a83b5984b846909192aa410393ca48
قاعدة البيانات: OpenAIRE